فاکتور رونویسی Sp1

SP1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1SP1, 1SP2, 1VA1, 1VA2, 1VA3
معین‌کننده‌ها
نام‌های دیگر	SP1, entrez:6667, Sp1 transcription factor
شناسه‌های بیرونی	OMIM: 189906 MGI: 98372 HomoloGene: 8276 GeneCards: SP1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۵ (موش)
پایان	102,344,839 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• protein homodimerization activity; • HMG box domain binding; • transcription factor binding; • histone deacetylase binding; • metal ion binding; • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; • bHLH transcription factor binding; • protein C-terminus binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • histone acetyltransferase binding; • nucleic acid binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • DNA binding; • double-stranded DNA binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • core promoter sequence-specific DNA binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0001158 cis-regulatory region sequence-specific DNA binding;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • protein-DNA complex; • هسته یاخته; • transcription repressor complex;
فرایند زیستی	• positive regulation of hydrogen sulfide biosynthetic process; • rhythmic process; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • GO:0022415 viral process; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • snRNA transcription by RNA polymerase II; • cellular response to insulin stimulus; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • regulation of cholesterol biosynthetic process; • GO:1901313 positive regulation of gene expression; • positive regulation of blood vessel endothelial cell migration; • positive regulation of angiogenesis; • positive regulation of vascular endothelial cell proliferation; • response to hydroperoxide;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6667
	20683
	ENSG00000185591
	ENSMUSG00000001280
	P08047
	O89090
	NM_003109، NM_138473 NM_001251825، NM_003109، NM_138473
	XM_017316523 NM_013672، XM_017316523
	NP_003100، NP_612482 NP_001238754، NP_003100، NP_612482
	XP_017172012 NP_038700، XP_017172012
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور رونویسی Sp1 (انگلیسی: Sp1 transcription factor) یک پروتئین است که در انسان توسط ژن «SP1» کُدگذاری می‌شود.^[۴]

این پروتئین در بسیاری از فرایندهای سلولی نظیر رشد سلول، خزان یاخته‌ای، پاسخ ایمنی، پاسخ به آسیب دی‌ان‌ای و بازآرایی کروماتین نقش دارد.

ویتافرین ای که از گیلاس زمستانی بدست می‌آید، این فاکتور رونویسی را مهار می‌کند.^[۵]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000001280 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Sp1 transcription factor".
↑ Prasanna KS, Shilpa P, Salimath BP (2009). "Withaferin A suppresses the expression of vascular endothelial growth factor in Ehrlich ascites tumor cells via Sp1 transcription" (PDF). Current Trends in Biotechnology and Pharmacy. 3 (2): 138–148. {{cite journal}}: Cite has empty unknown parameter: |month= (help)^{^{[پیوند مرده]}}

مشارکت‌کنندگان ویکی‌پدیا. «Sp1 transcription factor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

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