CREB1

CREB1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2LXT
معین‌کننده‌ها
نام‌های دیگر	CREB1, CREB, CREB-1, cAMP responsive element binding protein 1
شناسه‌های بیرونی	OMIM: 123810 MGI: 88494 HomoloGene: 3223 GeneCards: CREB1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	64,643,707 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • cAMP response element binding; • GO:0001104 transcription coregulator activity; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • enzyme binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • double-stranded DNA binding; • DNA binding; • sequence-specific DNA binding; • identical protein binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • transcription factor binding; • Hsp70 protein binding; • histone acetyltransferase binding; • arrestin family protein binding;
ترکیبات سلولی	• میتوکندری; • هسته یاخته; • ATF4-CREB1 transcription factor complex; • کروماتین; • transcription regulator complex; • نوکلئوپلاسم; • آسه; • mitochondrial matrix;
فرایند زیستی	• cellular response to nerve growth factor stimulus; • positive regulation of lipid biosynthetic process; • positive regulation of long-term synaptic potentiation; • rhythmic process; • cellular response to insulin-like growth factor stimulus; • transcription by RNA polymerase II; • response to organic substance; • mammary gland development; • protein phosphorylation; • type I pneumocyte differentiation; • ساعت زیستی; • positive regulation of multicellular organism growth; • response to L-glutamate; • lung saccule development; • lung epithelium development; • transforming growth factor beta receptor signaling pathway; • regulation of apoptotic process; • cellular response to transforming growth factor beta stimulus; • response to glucagon; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of transcription by competitive promoter binding; • response to nicotine; • positive regulation of osteoclast differentiation; • حافظه; • negative regulation of gene expression; • transcription, DNA-templated; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • lactation; • positive regulation of transforming growth factor beta3 production; • GO:0022415 viral process; • positive regulation of fat cell differentiation; • negative regulation of neuron death; • دگرگونی یاخته‌; • cellular response to hepatocyte growth factor stimulus; • protein stabilization; • cellular response to platelet-derived growth factor stimulus; • regulation of circadian rhythm; • secretory granule organization; • regulation of glial cell proliferation; • یادگیری بصری; • regulation of cell size; • pituitary gland development; • positive regulation of RNA polymerase II transcription preinitiation complex assembly; • response to hypoxia; • axonogenesis; • regulation of fibroblast proliferation; • cellular response to growth factor stimulus; • GO:0010260 پیرش; • chemotaxis to arachidonic acid; • response to activity; • cellular response to zinc ion; • cellular response to fatty acid; • positive regulation of apoptotic process; • positive regulation of hormone secretion; • GO:0072468 ورارسانی پیام; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of cardiac muscle tissue development; • cellular response to leukemia inhibitory factor; • cellular response to retinoic acid;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1385
	12912
	ENSG00000118260
	ENSMUSG00000025958
	P16220
	Q01147
	NM_134442، XM_011510646، XM_011510648، XM_011510650، XR_241290، XR_241292، NM_001320793، NR_135473، XM_017003399، XM_017003401، XR_001738636، XR_001738637، NM_001371426، NM_001371427، NM_001371428، NR_163946، NR_163947 NM_004379، NM_134442، XM_011510646، XM_011510648، XM_011510650، XR_241290، XR_241292، NM_001320793، NR_135473، XM_017003399، XM_017003401، XR_001738636، XR_001738637، NM_001371426، NM_001371427، NM_001371428، NR_163946، NR_163947
	NM_009952، NM_133828، XM_006495650، XM_006495651، XM_006495652، XM_006495653، XM_006495654، XM_006495655، XM_011238424، XM_011238425، XM_017314080، XM_017314099، XM_030245776، XM_036157655، XM_036157665، XR_004937537، XR_004937542، XR_004937550، XR_004937559، XR_004937560 NM_001037726، NM_009952، NM_133828، XM_006495650، XM_006495651، XM_006495652، XM_006495653، XM_006495654، XM_006495655، XM_011238424، XM_011238425، XM_017314080، XM_017314099، XM_030245776، XM_036157655، XM_036157665، XR_004937537، XR_004937542، XR_004937550، XR_004937559، XR_004937560
	NP_004370، NP_604391، XP_011508948، XP_011508950، XP_011508952، XP_016858888، XP_016858890، NP_001358355، NP_001358356، NP_001358357 NP_001307722، NP_004370، NP_604391، XP_011508948، XP_011508950، XP_011508952، XP_016858888، XP_016858890، NP_001358355، NP_001358356، NP_001358357
	NP_034082، NP_598589، XP_006495713، XP_006495714، XP_006495715، XP_006495716، XP_006495717، XP_006495718، XP_011236726، XP_011236727، XP_017169569، XP_017169588، XP_030101636، XP_036013548، XP_036013558 NP_001032815، NP_034082، NP_598589، XP_006495713، XP_006495714، XP_006495715، XP_006495716، XP_006495717، XP_006495718، XP_011236726، XP_011236727، XP_017169569، XP_017169588، XP_030101636، XP_036013548، XP_036013558
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ۱ متصل‌شونده به عامل واکنش‌دهنده به آدنوزین مونوفسفات حلقه‌ای (انگلیسی: CAMP responsive element binding protein 1) یک پروتئین است که در انسان توسط ژن «CREB1» کُدگذاری می‌شود.^[۴]^[۵] این پروتئین به عامل واکنش‌دهنده به آدنوزین مونوفسفات حلقه‌ای متصل می‌شود که یک توالی نوکلئوتیدی دی‌ان‌ای است که در پروموتر بسیاری از ویروس‌ها و سلول‌ها یافت می‌شود. این پروتئین در واقع یک فاکتور رونویسی CREB و عضوی از خانوادهٔ زیپ لوسین از پروتئین‌های دی‌ان‌ای پیوست است. این پروتئین همچنین توسط برخی پروتئین کینازها فسفریله شده و رونویسی ژنی را در پاسخ به تحریک هورومونی در مسیرهای آدنوزین مونوفسفات حلقه‌ای آغاز می‌کند. در اثر پیرایش دگرسان در این ژن، دو نسخهٔ رونویسی گوناگون حاصل می‌شود که ایزوفرم‌های متفاوتی را کُدگذاری می‌کنند.^[۶]

تعامل‌های شیمیایی[ویرایش]

این پروتئین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

CEBPB^[۷]
پروتئین متصل‌شونده به CREB^[۸]^[۹]^[۱۰]^[۱۱]^[۱۲]^[۱۳]^[۱۴]^[۱۵]^[۱۶]^[۱۷]
FHL2^[۱۸]
FHL3^[۱۸]
FHL5^[۱۸]
HTATIP^[۱۹]
پی۵۳^[۱۴] و
RPS6KA5^[۲۰]^[۲۱]

جستارهای وابسته[ویرایش]

CREB

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025958 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science. 242 (4884): 1430–3. Bibcode:1988Sci...242.1430H. doi:10.1126/science.2974179. PMID 2974179.
↑ Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (Jul 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics. 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID 2142119.
↑ "Entrez Gene: CREB1 cAMP responsive element binding protein 1".
↑ Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB (Jun 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Molecular and Cellular Biology. 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. PMC 156132. PMID 12773552.
↑ Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS (Apr 2004). "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 5898–903. Bibcode:2004PNAS..101.5898S. doi:10.1073/pnas.0307718101. PMC 395895. PMID 15073328.
↑ Kim J, Jia L, Stallcup MR, Coetzee GA (Feb 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". Journal of Molecular Endocrinology. 34 (1): 107–18. doi:10.1677/jme.1.01701. PMID 15691881.
↑ Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". The Journal of Biological Chemistry. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317.
↑ Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (Dec 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell. 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. PMID 9413984. S2CID 17268267.
↑ Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". The Journal of Biological Chemistry. 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. PMID 9786917.
↑ Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (Nov 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". The Journal of Biological Chemistry. 277 (44): 42241–8. doi:10.1074/jbc.M207361200. PMID 12196545.
↑ ^۱۴٫۰ ^۱۴٫۱ Giebler HA, Lemasson I, Nyborg JK (Jul 2000). "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Molecular and Cellular Biology. 20 (13): 4849–58. doi:10.1128/MCB.20.13.4849-4858.2000. PMC 85936. PMID 10848610.
↑ Zhang Q, Vo N, Goodman RH (Jul 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and Cellular Biology. 20 (14): 4970–8. doi:10.1128/MCB.20.14.4970-4978.2000. PMC 85947. PMID 10866654.
↑ Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (Apr 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. PMC 86859. PMID 11259575.
↑ Ledo F, Kremer L, Mellström B, Naranjo JR (Sep 2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". The EMBO Journal. 21 (17): 4583–92. doi:10.1093/emboj/cdf440. PMC 126180. PMID 12198160.
↑ ^۱۸٫۰ ^۱۸٫۱ ^۱۸٫۲ Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
↑ Gavaravarapu S, Kamine J (Mar 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and Biophysical Research Communications. 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. PMID 10720489.
↑ Deak M, Clifton AD, Lucocq LM, Alessi DR (Aug 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.
↑ Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (Aug 2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMC 125559. PMID 11500364.

مشارکت‌کنندگان ویکی‌پدیا. «CREB1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ دسامبر ۲۰۲۱.

برای مطالعهٔ بیشتر[ویرایش]

Don J, Stelzer G (Feb 2002). "The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis". Molecular and Cellular Endocrinology. 187 (1–2): 115–24. doi:10.1016/S0303-7207(01)00696-7. PMID 11988318. S2CID 23023082.
Pandey SC (Oct 2004). "The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction". Pharmacology & Therapeutics. 104 (1): 47–58. doi:10.1016/j.pharmthera.2004.08.002. PMID 15500908.
Wu H, Zhou Y, Xiong ZQ (Jul 2007). "Transducer of regulated CREB and late phase long-term synaptic potentiation". The FEBS Journal. 274 (13): 3218–23. doi:10.1111/j.1742-4658.2007.05891.x. PMID 17565597. S2CID 15804067.
Kitagawa K (Jul 2007). "CREB and cAMP response element-mediated gene expression in the ischemic brain". The FEBS Journal. 274 (13): 3210–7. doi:10.1111/j.1742-4658.2007.05890.x. PMID 17565598. S2CID 29917569.
Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599. S2CID 30323449.
Siu YT, Jin DY (Jul 2007). "CREB--a real culprit in oncogenesis". The FEBS Journal. 274 (13): 3224–32. doi:10.1111/j.1742-4658.2007.05884.x. PMID 17565603. S2CID 39040147.

پیوند به بیرون[ویرایش]

CREB1 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CREB1 انسانی و صفحهٔ جزئیات ژنی CREB1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000025958 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2974179-4] Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF (Dec 1988). "Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA". Science. 242 (4884): 1430–3. Bibcode:1988Sci...242.1430H. doi:10.1126/science.2974179. PMID 2974179.

[pmid2142119-5] Taylor AK, Klisak I, Mohandas T, Sparkes RS, Li C, Gaynor R, Lusis AJ (Jul 1990). "Assignment of the human gene for CREB1 to chromosome 2q32.3-q34". Genomics. 7 (3): 416–21. doi:10.1016/0888-7543(90)90176-U. PMID 2142119.

[6] "Entrez Gene: CREB1 cAMP responsive element binding protein 1".

[pmid12773552-7] Chen Y, Zhuang S, Cassenaer S, Casteel DE, Gudi T, Boss GR, Pilz RB (Jun 2003). "Synergism between calcium and cyclic GMP in cyclic AMP response element-dependent transcriptional regulation requires cooperation between CREB and C/EBP-beta". Molecular and Cellular Biology. 23 (12): 4066–82. doi:10.1128/MCB.23.12.4066-4082.2003. PMC 156132. PMID 12773552.

[pmid15073328-8] Shi Y, Venkataraman SL, Dodson GE, Mabb AM, LeBlanc S, Tibbetts RS (Apr 2004). "Direct regulation of CREB transcriptional activity by ATM in response to genotoxic stress". Proceedings of the National Academy of Sciences of the United States of America. 101 (16): 5898–903. Bibcode:2004PNAS..101.5898S. doi:10.1073/pnas.0307718101. PMC 395895. PMID 15073328.

[pmid15691881-9] Kim J, Jia L, Stallcup MR, Coetzee GA (Feb 2005). "The role of protein kinase A pathway and cAMP responsive element-binding protein in androgen receptor-mediated transcription at the prostate-specific antigen locus". Journal of Molecular Endocrinology. 34 (1): 107–18. doi:10.1677/jme.1.01701. PMID 15691881.

[pmid8663317-10] Shimomura A, Ogawa Y, Kitani T, Fujisawa H, Hagiwara M (Jul 1996). "Calmodulin-dependent protein kinase II potentiates transcriptional activation through activating transcription factor 1 but not cAMP response element-binding protein". The Journal of Biological Chemistry. 271 (30): 17957–60. doi:10.1074/jbc.271.30.17957. PMID 8663317.

[pmid9413984-11] Radhakrishnan I, Pérez-Alvarado GC, Parker D, Dyson HJ, Montminy MR, Wright PE (Dec 1997). "Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions". Cell. 91 (6): 741–52. doi:10.1016/S0092-8674(00)80463-8. PMID 9413984. S2CID 17268267.

[pmid9786917-12] Sano Y, Tokitou F, Dai P, Maekawa T, Yamamoto T, Ishii S (Oct 1998). "CBP alleviates the intramolecular inhibition of ATF-2 function". The Journal of Biological Chemistry. 273 (44): 29098–105. doi:10.1074/jbc.273.44.29098. PMID 9786917.

[pmid12196545-13] Zor T, Mayr BM, Dyson HJ, Montminy MR, Wright PE (Nov 2002). "Roles of phosphorylation and helix propensity in the binding of the KIX domain of CREB-binding protein by constitutive (c-Myb) and inducible (CREB) activators". The Journal of Biological Chemistry. 277 (44): 42241–8. doi:10.1074/jbc.M207361200. PMID 12196545.

[pmid10848610-14] ۱۴٫۰ ^۱۴٫۱ Giebler HA, Lemasson I, Nyborg JK (Jul 2000). "p53 recruitment of CREB binding protein mediated through phosphorylated CREB: a novel pathway of tumor suppressor regulation". Molecular and Cellular Biology. 20 (13): 4849–58. doi:10.1128/MCB.20.13.4849-4858.2000. PMC 85936. PMID 10848610.

[pmid10866654-15] Zhang Q, Vo N, Goodman RH (Jul 2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB". Molecular and Cellular Biology. 20 (14): 4970–8. doi:10.1128/MCB.20.14.4970-4978.2000. PMC 85947. PMID 10866654.

[pmid11259575-16] Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ (Apr 2001). "MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein". Molecular and Cellular Biology. 21 (7): 2249–58. doi:10.1128/MCB.21.7.2249-2258.2001. PMC 86859. PMID 11259575.

[pmid12198160-17] Ledo F, Kremer L, Mellström B, Naranjo JR (Sep 2002). "Ca2+-dependent block of CREB-CBP transcription by repressor DREAM". The EMBO Journal. 21 (17): 4583–92. doi:10.1093/emboj/cdf440. PMC 126180. PMID 12198160.

[pmid11046156-18] ۱۸٫۰ ^۱۸٫۱ ^۱۸٫۲ Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Molecular and Cellular Biology. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.

[pmid10720489-19] Gavaravarapu S, Kamine J (Mar 2000). "Tip60 inhibits activation of CREB protein by protein kinase A". Biochemical and Biophysical Research Communications. 269 (3): 758–66. doi:10.1006/bbrc.2000.2358. PMID 10720489.

[pmid9687510-20] Deak M, Clifton AD, Lucocq LM, Alessi DR (Aug 1998). "Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB". The EMBO Journal. 17 (15): 4426–41. doi:10.1093/emboj/17.15.4426. PMC 1170775. PMID 9687510.

[pmid-21] Wang X, Li W, Williams M, Terada N, Alessi DR, Proud CG (Aug 2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". The EMBO Journal. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMC 125559. PMID 11500364.

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