TFG

TFG
معین‌کننده‌ها
نام‌های دیگر	TFG, HMSNP, SPG57, TF6, TRKT3, TRK-fused gene, trafficking from ER to golgi regulator
شناسه‌های بیرونی	OMIM: 602498 MGI: 1338041 HomoloGene: 4426 GeneCards: TFG
موقعیت ژن (موش) کروموزوم کروموزوم ۱۶ (موش) نوار 16|16 C1.1 شروع 56,510,695 bp پایان 56,537,813 bp
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GO:0001948، GO:0016582 پیوند پروتئینی • signal transducer activity • identical protein binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • extracellular exosome • Golgi membrane • endoplasmic reticulum exit site • شبکه آندوپلاسمی فرایند زیستی • positive regulation of I-kappaB kinase/NF-kappaB signaling • GO:0072468 ورارسانی پیام • endoplasmic reticulum to Golgi vesicle-mediated transport • COPII vesicle coating منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	10342	21787
آنسامبل	ENSG00000114354	ENSMUSG00000022757
یونی‌پروت	Q92734	ن/م
RefSeq (mRNA)	NM_001007565، NM_001195478، NM_001195479، NM_006070، XM_005247066، XM_006713472، XM_017005527، XM_047447241، XM_047447242، XM_047447243، XM_047447244 XM_011512334، NM_001007565، NM_001195478، NM_001195479، NM_006070، XM_005247066، XM_006713472، XM_017005527، XM_047447241، XM_047447242، XM_047447243، XM_047447244	NM_019678، XM_006521980، NM_001357124، NM_001357125، NM_001357126 NM_001252443، NM_019678، XM_006521980، NM_001357124، NM_001357125، NM_001357126
RefSeq (پروتئین)	NP_001182407، NP_001182408، NP_006061، XP_005247123، XP_006713535، XP_011510636، XP_016861016 NP_001007566، NP_001182407، NP_001182408، NP_006061، XP_005247123، XP_006713535، XP_011510636، XP_016861016	ن/م
موقعیت (UCSC)	ن/م	Chr : 56.51 – 56.54 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

پروتئین TFG (انگلیسی: Protein TFG) یک پروتئین است که در انسان توسط ژن «TFG» کدگذاری می‌شود.

منابع

• مشارکت‌کنندگان ویکی‌پدیا. «TFG (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۷ اکتبر ۲۰۱۸.

بیشتر بخوانید

• Sasaoka T, Kobayashi M (Aug 2000). "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor". Endocrine Journal. 47 (4): 373–81. doi:10.1507/endocrj.47.373. PMID 11075717.
• Greco A, Mariani C, Miranda C, Lupas A, Pagliardini S, Pomati M, Pierotti MA (Nov 1995). "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain". Molecular and Cellular Biology. 15 (11): 6118–27. doi:10.1128/mcb.15.11.6118. PMC 230863. PMID 7565764.
• Gotoh N, Toyoda M, Shibuya M (Apr 1997). "Tyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activation". Molecular and Cellular Biology. 17 (4): 1824–31. doi:10.1128/mcb.17.4.1824. PMC 232029. PMID 9121430.
• Soltoff SP, Avraham H, Avraham S, Cantley LC (Jan 1998). "Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C". The Journal of Biological Chemistry. 273 (5): 2653–60. doi:10.1074/jbc.273.5.2653. PMID 9446569.
• Walk SF, March ME, Ravichandran KS (Aug 1998). "Roles of Lck, Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc". European Journal of Immunology. 28 (8): 2265–75. doi:10.1002/(SICI)1521-4141(199808)28:08<2265::AID-IMMU2265>3.0.CO;2-P. PMID 9710204.
• Wary KK, Mariotti A, Zurzolo C, Giancotti FG (Sep 1998). "A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth". Cell. 94 (5): 625–34. doi:10.1016/S0092-8674(00)81604-9. PMID 9741627.
• Marchetto S, Fournier E, Beslu N, Aurran-Schleinitz T, Dubreuil P, Borg JP, Birnbaum D, Rosnet O (Sep 1999). "SHC and SHIP phosphorylation and interaction in response to activation of the FLT3 receptor". Leukemia. 13 (9): 1374–82. doi:10.1038/sj/leu/2401527. PMID 10482988.
• Hernández L, Pinyol M, Hernández S, Beà S, Pulford K, Rosenwald A, Lamant L, Falini B, Ott G, Mason DY, Delsol G, Campo E (Nov 1999). "TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations". Blood. 94 (9): 3265–8. PMID 10556217.
• Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K (Jul 2000). "Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells". The Journal of Biological Chemistry. 275 (27): 20880–6. doi:10.1074/jbc.M905410199. PMID 10764799.
• Slack BE (Jun 2000). "The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase". The Biochemical Journal. 348 (2): 381–7. doi:10.1042/0264-6021:3480381. PMC 1221077. PMID 10816433.
• Schaak S, Cussac D, Cayla C, Devedjian JC, Guyot R, Paris H, Denis C (Aug 2000). "Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells". Gut. 47 (2): 242–50. doi:10.1136/gut.47.2.242. PMC 1728001. PMID 10896916.
• Imokawa G, Kobayasi T, Miyagishi M (Oct 2000). "Intracellular signaling mechanisms leading to synergistic effects of endothelin-1 and stem cell factor on proliferation of cultured human melanocytes. Cross-talk via trans-activation of the tyrosine kinase c-kit receptor". The Journal of Biological Chemistry. 275 (43): 33321–8. doi:10.1074/jbc.M004346200. PMID 10921922.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Hernández L, Beà S, Bellosillo B, Pinyol M, Falini B, Carbone A, Ott G, Rosenwald A, Fernández A, Pulford K, Mason D, Morris SW, Santos E, Campo E (Apr 2002). "Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity". The American Journal of Pathology. 160 (4): 1487–94. doi:10.1016/S0002-9440(10)62574-6. PMC 1867210. PMID 11943732.
• Roccato E, Miranda C, Ranzi V, Gishizki M, Pierotti MA, Greco A (Sep 2002). "Biological activity of the thyroid TRK-T3 oncogene requires signalling through Shc". British Journal of Cancer. 87 (6): 645–53. doi:10.1038/sj.bjc.6600544. PMC 2364237. PMID 12237775.
• Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (May 2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.

پیوند به بیرون

• مکان ژن انسانی TFG در مرورگر ژنومی UCSC.
• جزئیات ژن انسانی TFG در مرورگر ژنومی UCSC.