TEGT

TMBIM6
معین‌کننده‌ها
نام‌های دیگر	TMBIM6, BAXI1, BI-1, TEGT, transmembrane BAX inhibitor motif containing 6
شناسه‌های بیرونی	OMIM: 600748 MGI: 99682 HomoloGene: 2419 GeneCards: TMBIM6
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۵ (موش)
پایان	99,307,930 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• endoribonuclease inhibitor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • enzyme binding; • ubiquitin protein ligase binding;
ترکیبات سلولی	• سیتوپلاسم; • integral component of membrane; • endoplasmic reticulum membrane; • membrane; • mitochondrial membranes; • integral component of plasma membrane; • شبکه آندوپلاسمی; • هسته یاخته;
فرایند زیستی	• negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; • negative regulation of endoribonuclease activity; • negative regulation of apoptotic signaling pathway; • negative regulation of apoptotic process; • negative regulation of protein binding; • endoplasmic reticulum calcium ion homeostasis; • response to endoplasmic reticulum stress; • خودخواری; • response to unfolded protein; • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; • response to L-glutamate; • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; • negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • negative regulation of calcium ion transport into cytosol; • negative regulation of RNA splicing; • Unfolded Protein Response;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7009
	110213
	ENSG00000139644
	ENSMUSG00000023010
	P55061
	Q9D2C7
	NM_001098576، NM_003217 XM_005269126، NM_001098576، NM_003217
	NM_001171035، NM_001171036، NM_026669، XM_036159068 NM_001171034، NM_001171035، NM_001171036، NM_026669، XM_036159068
	NP_003208، XP_005269183، XP_024304937، XP_024304938، XP_024304939، XP_024304940، XP_024304941، XP_024304942 NP_001092046، NP_003208، XP_005269183، XP_024304937، XP_024304938، XP_024304939، XP_024304940، XP_024304941، XP_024304942
	NP_001164506، NP_001164507، NP_080945، XP_036014961 NP_001164505، NP_001164506، NP_001164507، NP_080945، XP_036014961
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

بازدارنده ۱ باکس پروتئینی است که در انسان توسط ژن TMBIM6 کدگذاری می‌شود.^[۴]^[۵]^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000023010 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.
↑ Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.
↑ "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

جهت مطالعه[ویرایش]

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Cowling RT, Birnboim HC (1999). "Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT)". Mol. Membr. Biol. 15 (4): 177–87. doi:10.3109/09687689709044319. PMID 10087504.
Jean JC, Oakes SM, Joyce-Brady M (1999). "The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters". Genomics. 57 (2): 201–8. doi:10.1006/geno.1999.5761. PMID 10198159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Grzmil M, Thelen P, Hemmerlein B, et al. (2003). "Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells". Am. J. Pathol. 163 (2): 543–52. doi:10.1016/S0002-9440(10)63682-6. PMC 1868227. PMID 12875974.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Tanaka R, Ishiyama T, Uchihara T, et al. (2006). "Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma". Cancer. 106 (3): 648–53. doi:10.1002/cncr.21639. PMID 16353209. S2CID 1629852.
Lee GH, Kim HK, Chae SW, et al. (2007). "Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression". J. Biol. Chem. 282 (30): 21618–28. doi:10.1074/jbc.M700053200. PMID 17526500.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000023010 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_8530040-4] Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.

[pmid_9660918-5] Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.

[entrez-6] "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

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