SKP1A

SKP1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1FQV, 1FS1, 1FS2, 1LDK, 1P22, 2ASS, 2AST, 2E31, 2E32, 2OVP, 2OVQ, 2OVR, 3L2O, 3WSO, 4I6J, 5IBK
معین‌کننده‌ها
نام‌های دیگر	SKP1, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, S-phase kinase associated protein 1
شناسه‌های بیرونی	OMIM: 601434 MGI: 103575 HomoloGene: 38775 GeneCards: SKP1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	52,137,685 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• cullin family protein binding; • beta-catenin binding; • GO:1904264، GO:1904822، GO:0090622، GO:0090302 ubiquitin protein ligase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0050372 ubiquitin-protein transferase activity; • protein domain specific binding;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • PcG protein complex; • هسته یاخته; • سیتوزول; • SCF ubiquitin ligase complex; • Cul7-RING ubiquitin ligase complex; • میان‌تن;
فرایند زیستی	• ubiquitin-dependent protein catabolic process; • histone H2A monoubiquitination; • NIK/NF-kappaB signaling; • G2/M transition of mitotic cell cycle; • stress-activated MAPK cascade; • protein ubiquitination; • protein polyubiquitination; • Wnt signaling pathway; • SCF complex assembly; • negative regulation of G2/M transition of mitotic cell cycle; • maintenance of protein location in nucleus; • cellular iron ion homeostasis; • پیرایش پسارونویسی; • interleukin-1-mediated signaling pathway; • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; • GO:0022415 viral process; • regulation of mitotic cell cycle phase transition; • stimulatory C-type lectin receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • T cell receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6500
	21402
	ENSG00000113558
	ENSMUSG00000036309
	P63208
	Q9WTX5
	NM_006930 NM_170679، NM_006930
	XM_006532786، XM_036156505 NM_011543، XM_006532786، XM_036156505
	NP_733779 NP_008861، NP_733779
	XP_006532849، XP_036012398 NP_035673، XP_006532849، XP_036012398
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین ۱ مرتبط با کیناز مرحله اس (انگلیسی: S-phase kinase-associated protein 1) یک پروتئین است که در انسان توسط ژن «SKP1» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

این مولکول با پروتئین‌های گوناگونی چون FBXO5^[۷] تعامل پروتئین-پروتئین دارد.

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000036309 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang H, Kobayashi R, Galaktionov K, Beach D (October 1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase". Cell. 82 (6): 915–25. doi:10.1016/0092-8674(95)90271-6. PMID 7553852.
↑ Demetrick DJ, Zhang H, Beach DH (July 1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)". Cytogenet Cell Genet. 73 (1–2): 104–7. doi:10.1159/000134318. PMID 8646875.
↑ "Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)".
↑ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

مشارکت‌کنندگان ویکی‌پدیا. «SKP1A». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۳ مارس ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

Chen H, Thalmann I, Adams JC, Avraham KB, Copeland NG, Jenkins NA, Beier DR, Corey DP, Thalmann R, Duyk GM (1995). "cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs". Genomics. 27 (3): 389–98. doi:10.1006/geno.1995.1068. PMID 7558018.
Sowden J, Morrison K, Schofield J, Putt W, Edwards Y (1996). "A novel cDNA with homology to an RNA polymerase II elongation factor maps to human chromosome 5q31 (TCEB1L) and to mouse chromosome 11 (Tceb1l)". Genomics. 29 (1): 145–51. doi:10.1006/geno.1995.1225. PMID 8530064.
Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ (1996). "SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box". Cell. 86 (2): 263–74. doi:10.1016/S0092-8674(00)80098-7. PMID 8706131.
Brown KA, Leek JP, Lench NJ, Moynihan LM, Markham AF, Mueller RF (1996). "Human sequences homologous to the gene for the cochlear protein Ocp-II do not map to currently known non-syndromic hearing loss loci". Ann. Hum. Genet. 60 (Pt 5): 385–9. doi:10.1111/j.1469-1809.1996.tb00436.x. PMID 8912791.
Liang Y, Chen H, Asher JH, Chang CC, Friedman TB (1997). "Human inner ear OCP2 cDNA maps to 5q22-5q35.2 with related sequences on chromosomes 4p16.2-4p14, 5p13-5q22, 7pter-q22, 10 and 12p13-12qter". Gene. 184 (2): 163–7. doi:10.1016/S0378-1119(96)00590-2. PMID 9031623.
Lisztwan J, Marti A, Sutterlüty H, Gstaiger M, Wirbelauer C, Krek W (1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway". EMBO J. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMC 1170388. PMID 9430629.
Ng RW, Arooz T, Yam CH, Chan IW, Lau AW, Poon RY (1998). "Characterization of the cullin and F-box protein partner Skp1". FEBS Lett. 438 (3): 183–9. doi:10.1016/S0014-5793(98)01299-X. PMID 9827542.
Yam CH, Ng RW, Siu WY, Lau AW, Poon RY (1999). "Regulation of cyclin A-Cdk2 by SCF component Skp1 and F-box protein Skp2". Mol. Cell. Biol. 19 (1): 635–45. doi:10.1128/mcb.19.1.635. PMC 83921. PMID 9858587.
Henzl MT, Thalmann I, Thalmann R (1999). "OCP2 exists as a dimer in the organ of Corti". Hear. Res. 126 (1–2): 37–46. doi:10.1016/S0378-5955(98)00148-8. PMID 9872132.
Winston JT, Strack P, Beer-Romero P, Chu CY, Elledge SJ, Harper JW (1999). "The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro". Genes Dev. 13 (3): 270–83. doi:10.1101/gad.13.3.270. PMC 316433. PMID 9990852.
Ilyin GP, Rialland M, Glaise D, Guguen-Guillouzo C (1999). "Identification of a novel Skp2-like mammalian protein containing F-box and leucine-rich repeats". FEBS Lett. 459 (1): 75–9. doi:10.1016/S0014-5793(99)01211-9. PMID 10508920.
Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K (2000). "Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination". J. Biol. Chem. 275 (4): 2877–84. doi:10.1074/jbc.275.4.2877. PMID 10644755.
Read MA, Brownell JE, Gladysheva TB, Hottelet M, Parent LA, Coggins MB, Pierce JW, Podust VN, Luo RS, Chau V, Palombella VJ (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha". Mol. Cell. Biol. 20 (7): 2326–33. doi:10.1128/MCB.20.7.2326-2333.2000. PMC 85397. PMID 10713156.
Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP (2000). "Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex". Nature. 408 (6810): 381–6. doi:10.1038/35042620. PMID 11099048.
Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ (2001). "Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome". Science. 292 (5520): 1382–5. doi:10.1126/science.1059780. PMID 11337588.
Fukuchi M, Imamura T, Chiba T, Ebisawa T, Kawabata M, Tanaka K, Miyazono K (2001). "Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins". Mol. Biol. Cell. 12 (5): 1431–43. doi:10.1091/mbc.12.5.1431. PMC 34595. PMID 11359933.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000036309 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7553852-4] Zhang H, Kobayashi R, Galaktionov K, Beach D (October 1995). "p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase". Cell. 82 (6): 915–25. doi:10.1016/0092-8674(95)90271-6. PMID 7553852.

[pmid8646875-5] Demetrick DJ, Zhang H, Beach DH (July 1996). "Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2)". Cytogenet Cell Genet. 73 (1–2): 104–7. doi:10.1159/000134318. PMID 8646875.

[entrez-6] "Entrez Gene: SKP1A S-phase kinase-associated protein 1A (p19A)".

[pmid10531035-7] Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

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