SH3GL3

SH3GL3
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2EW3, 2Z0V
معین‌کننده‌ها
نام‌های دیگر	SH3GL3, CNSA3, EEN-B2, HsT19371, SH3D2C, SH3P13, SH3 domain containing GRB2 like endophilin A3, SH3 domain containing GRB2 like 3, endophilin A3
شناسه‌های بیرونی	OMIM: 603362 MGI: 700011 HomoloGene: 37723 GeneCards: SH3GL3
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	82,307,419 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • lipid binding; • protein C-terminus binding;
ترکیبات سلولی	• سیتوپلاسم; • اندوزوم; • early endosome; • early endosome membrane; • membrane; • آکروزوم; • سیناپس; • presynapse; • postsynaptic endosome; • glutamatergic synapse; • postsynaptic density, intracellular component;
فرایند زیستی	• central nervous system development; • اندوسیتوز; • GO:0072468 ورارسانی پیام; • positive regulation of neuron differentiation; • negative regulation of clathrin-dependent endocytosis; • regulation of clathrin-dependent endocytosis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6457
	20408
	ENSG00000140600
	ENSMUSG00000030638
	Q99963
	Q62421
	NM_001301109، NM_003027، NR_125370، XM_011521889، XM_011521892، XR_931879، NM_001324182، NM_001324183، NM_001324184، NM_001324185، NM_001324186، NM_001324187، NR_136711، NR_136712، NR_136713، NR_136714، XM_017022486، XR_001751372، XM_047432940، XR_007064483، XR_007064484، XR_007064485، XR_007064486 NM_001301108، NM_001301109، NM_003027، NR_125370، XM_011521889، XM_011521892، XR_931879، NM_001324182، NM_001324183، NM_001324184، NM_001324185، NM_001324186، NM_001324187، NR_136711، NR_136712، NR_136713، NR_136714، XM_017022486، XR_001751372، XM_047432940، XR_007064483، XR_007064484، XR_007064485، XR_007064486
	NM_001277955، NM_017400 NM_001277954، NM_001277955، NM_017400
	NP_001288038، NP_001311111، NP_001311112، NP_001311113، NP_001311114، NP_001311115، NP_001311116، NP_003018، XP_011520191، XP_011520193، XP_011520194، XP_016877975، XP_024305785 NP_001288037، NP_001288038، NP_001311111، NP_001311112، NP_001311113، NP_001311114، NP_001311115، NP_001311116، NP_003018، XP_011520191، XP_011520193، XP_011520194، XP_016877975، XP_024305785
	NP_001264884، NP_059096، XP_030098122، XP_030098123، XP_030098124، XP_030098126، XP_030098129، XP_036008715، XP_036008716، XP_036008717، XP_036008718 NP_001264883، NP_001264884، NP_059096، XP_030098122، XP_030098123، XP_030098124، XP_030098126، XP_030098129، XP_036008715، XP_036008716، XP_036008717، XP_036008718
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

اندوفیلین-A3 (انگلیسی: Endophilin-A3) یک پروتئین است که در انسان توسط ژن «SH3GL3» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین با هانتینگتین، تعامل پروتئین-پروتئین دارد.^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030638 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
↑ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".
↑ Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064.

مشارکت‌کنندگان ویکی‌پدیا. «SH3GL3». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۹ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ, Sham MH, Wiedemann LM, Chan LC (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. doi:10.1073/pnas.94.6.2563. PMC 20128. PMID 9122235.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. doi:10.1073/pnas.94.16.8569. PMC 23017. PMID 9238017.
Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064.
Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990. PMID 10535961.
Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmüller U, Schneider-Mergener J, Cesareni G (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis". Leukemia. 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
So CW, Sham MH, Chew SL, Cheung N, So CK, Chung SK, Caldas C, Wiedemann LM, Chan LC (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins". Biochem. J. 348 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085. PMID 10816441.
Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.
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Otsuki M, Itoh T, Takenawa T (2003). "Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor". J. Biol. Chem. 278 (8): 6461–9. doi:10.1074/jbc.M207433200. PMID 12477732.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030638 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169142-4] Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.

[entrez-5] "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".

[pmid9809064-6] Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064.

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