PRKAA1

PRKAA1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4RED, 4RER, 4REW, 5EZV
معین‌کننده‌ها
نام‌های دیگر	PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
شناسه‌های بیرونی	OMIM: 602739 MGI: 2145955 HomoloGene: 49590 GeneCards: PRKAA1
عدد EC	2.7.11.26
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۵ (موش)
پایان	5,211,380 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • cAMP-dependent protein kinase activity; • [acetyl-CoA carboxylase kinase activity]; • AMP-activated protein kinase activity; • histone serine kinase activity; • chromatin binding; • metal ion binding; • kinase activity; • protein serine/threonine kinase activity; • tau-protein kinase activity; • protein C-terminus binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity]; • ATP binding; • tau protein binding;
ترکیبات سلولی	• nucleotide-activated protein kinase complex; • apical plasma membrane; • نوکلئوپلاسم; • هسته یاخته; • سیتوپلاسم; • سیتوزول; • nuclear speck; • intracellular anatomical structure; • آسه; • دندریت; • GO:0009327 protein-containing complex; • neuronal cell body;
فرایند زیستی	• cellular response to organonitrogen compound; • steroid metabolic process; • cellular response to glucose starvation; • sterol biosynthetic process; • lipid biosynthetic process; • GO:0009373 regulation of transcription, DNA-templated; • response to hypoxia; • cellular response to ethanol; • glucose homeostasis; • positive regulation of skeletal muscle tissue development; • protein heterooligomerization; • rhythmic process; • فسفرگیری; • سوخت‌وساز لیپید; • regulation of vesicle-mediated transport; • negative regulation of apoptotic process; • cholesterol metabolic process; • Wnt signaling pathway; • response to activity; • Synthesis saturated fatty acids by metabolites; • transcription, DNA-templated; • cellular response to prostaglandin E stimulus; • خودخواری; • protein phosphorylation; • negative regulation of TOR signaling; • cold acclimation; • GO:1901313 positive regulation of gene expression; • response to camptothecin; • fatty acid biosynthetic process; • fatty acid homeostasis; • regulation of circadian rhythm; • fatty acid oxidation; • regulation of peptidyl-serine phosphorylation; • cellular response to nutrient levels; • positive regulation of cell population proliferation; • negative regulation of glucosylceramide biosynthetic process; • glucose metabolic process; • positive regulation of cholesterol biosynthetic process; • response to caffeine; • cholesterol biosynthetic process; • negative regulation of lipid catabolic process; • واکنش به پرتو گاما; • macroautophagy; • واکنش به فرابنفش; • positive regulation of glycolytic process; • response to hydrogen peroxide; • cellular response to hypoxia; • GO:0072468 ورارسانی پیام; • cellular response to hydrogen peroxide; • steroid biosynthetic process; • regulation of signal transduction by p53 class mediator; • positive regulation of autophagy; • CAMKK-AMPK signaling cascade; • regulation of macroautophagy; • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization; • positive regulation of mitochondrial transcription; • positive regulation of protein targeting to mitochondrion; • negative regulation of gene expression; • cellular response to oxidative stress; • GO:0007243 intracellular signal transduction; • GO:1903105 negative regulation of insulin receptor signaling pathway; • motor behavior; • regulation of stress granule assembly; • neuron cellular homeostasis; • regulation of microtubule cytoskeleton organization; • cellular response to calcium ion; • cellular response to glucose stimulus; • energy homeostasis; • positive regulation of protein localization; • negative regulation of tubulin deacetylation; • positive regulation of peptidyl-lysine acetylation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5562
	105787
	ENSG00000132356
	ENSMUSG00000050697
	Q13131
	Q5EG47
	NM_006251، NM_206907، XM_017009624، XM_017009625 XM_006714482، NM_006251، NM_206907، XM_017009624، XM_017009625
	NM_001355640، XM_036159053 NM_001013367، NM_001355640، XM_036159053
	NP_996790، XP_016865113، XP_016865114، NP_001341957، NP_001341958، NP_001341963، NP_001341964، NP_001341965، NP_001341966 NP_006242، NP_996790، XP_016865113، XP_016865114، NP_001341957، NP_001341958، NP_001341963، NP_001341964، NP_001341965، NP_001341966
	NP_001342569، XP_036014946 NP_001013385، NP_001342569، XP_036014946
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زیرواحد آلفا-۱ کاتالیتیک پروتئین کیناز فعال‌شده با ۵'-آدنوزین مونوفسفات (انگلیسی: 5'-AMP-activated protein kinase catalytic subunit alpha-1) که با نام «AMPKa1» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «PRKAA1» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین متعلق به خانوادهٔ پروتئین کینازهای اختصاصی سرین/ترئونین است. ثابت شده که طی پیرایش دگرسان، نسخهٔ‌های رونویسی مختلفی از این ژن که ایزوفرم‌های گوناگونی را پدیدمی‌آوردند، به وجود می‌آید.^[۵]

این پروتئین با مولکول TSC2^[۶]^[۷] تعامل پروتئین-پروتئین دارد.

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000050697 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.
↑ ^۵٫۰ ^۵٫۱ "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".
↑ Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. United States. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. S2CID 18173817.
↑ Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. United States. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145.

مشارکت‌کنندگان ویکی‌پدیا. «Protein kinase, AMP-activated, alpha 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر[ویرایش]

Munday MR, Campbell DG, Carling D, Hardie DG (1988). "Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase". Eur. J. Biochem. 175 (2): 331–8. doi:10.1111/j.1432-1033.1988.tb14201.x. PMID 2900138.
Woods A, Cheung PC, Smith FC, et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro". J. Biol. Chem. 271 (17): 10282–90. doi:10.1074/jbc.271.48.30517. PMID 8626596.
Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase". J. Biol. Chem. 271 (44): 27879–87. doi:10.1074/jbc.271.44.27879. PMID 8910387.
Stapleton D, Woollatt E, Mitchelhill KI, et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location". FEBS Lett. 409 (3): 452–6. doi:10.1016/S0014-5793(97)00569-3. PMID 9224708. S2CID 39329574.
Velasco G, Gómez del Pulgar T, Carling D, Guzmán M (1998). "Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components". FEBS Lett. 439 (3): 317–20. doi:10.1016/S0014-5793(98)01400-8. PMID 9845345. S2CID 29493620.
Crute BE, Seefeld K, Gamble J, et al. (1999). "Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase". J. Biol. Chem. 273 (52): 35347–54. doi:10.1074/jbc.273.52.35347. PMID 9857077.
da Silva Xavier G, Leclerc I, Salt IP, et al. (2000). "Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4023–8. Bibcode:2000PNAS...97.4023D. doi:10.1073/pnas.97.8.4023. PMC 18135. PMID 10760274.
Hallows KR, Raghuram V, Kemp BE, et al. (2000). "Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase". J. Clin. Invest. 105 (12): 1711–21. doi:10.1172/JCI9622. PMC 378514. PMID 10862786.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Chen ZP, McConell GK, Michell BJ, et al. (2000). "AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation". Am. J. Physiol. Endocrinol. Metab. 279 (5): E1202–6. doi:10.1152/ajpendo.2000.279.5.E1202. PMID 11052978. S2CID 13387968.
Blázquez C, Geelen MJ, Velasco G, Guzmán M (2001). "The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes". FEBS Lett. 489 (2–3): 149–53. doi:10.1016/S0014-5793(01)02089-0. PMID 11165240. S2CID 35584617.
Diggle TA, Subkhankulova T, Lilley KS, et al. (2001). "Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity". Biochem. J. 353 (Pt 3): 621–6. doi:10.1042/0264-6021:3530621. PMC 1221608. PMID 11171059.
Wang X, Li W, Williams M, et al. (2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". EMBO J. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMC 125559. PMID 11500364.
Xi X, Han J, Zhang JZ (2001). "Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase". J. Biol. Chem. 276 (44): 41029–34. doi:10.1074/jbc.M102824200. PMID 11546797.
Fryer LG, Foufelle F, Barnes K, et al. (2002). "Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells". Biochem. J. 363 (Pt 1): 167–74. doi:10.1042/0264-6021:3630167. PMC 1222463. PMID 11903059.
Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling". J. Biol. Chem. 277 (27): 23977–80. doi:10.1074/jbc.C200171200. PMID 11997383.
Esumi H, Izuishi K, Kato K, et al. (2002). "Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner". J. Biol. Chem. 277 (36): 32791–8. doi:10.1074/jbc.M112270200. PMID 12091379.
Horman S, Browne G, Krause U, et al. (2003). "Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis". Curr. Biol. 12 (16): 1419–23. doi:10.1016/S0960-9822(02)01077-1. PMID 12194824. S2CID 9865400.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000050697 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8557660-4] Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE (Feb 1996). "Mammalian AMP-activated protein kinase subfamily". J Biol Chem. 271 (2): 611–4. doi:10.1074/jbc.271.2.611. PMID 8557660.

[entrez-5] ۵٫۰ ^۵٫۱ "Entrez Gene: PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit".

[pmid14651849-6] Inoki, Ken; Zhu Tianqing; Guan Kun-Liang (Nov 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. United States. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. ISSN 0092-8674. PMID 14651849. S2CID 18173817.

[pmid15261145-7] Shaw, Reuben J; Bardeesy Nabeel; Manning Brendan D; Lopez Lyle; Kosmatka Monica; DePinho Ronald A; Cantley Lewis C (Jul 2004). "The LKB1 tumor suppressor negatively regulates mTOR signaling". Cancer Cell. United States. 6 (1): 91–9. doi:10.1016/j.ccr.2004.06.007. ISSN 1535-6108. PMID 15261145.

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