PPP4C

PPP4C
معین‌کننده‌ها
نام‌های دیگر	PPP4C, PP4, PP4C, PPH3, PPP4, PPX, PP-X, protein phosphatase 4 catalytic subunit
شناسه‌های بیرونی	OMIM: 602035 MGI: 1891763 HomoloGene: 2038 GeneCards: PPP4C
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	126,391,668 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• phosphoprotein phosphatase activity; • metal ion binding; • NF-kappaB-inducing kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • hydrolase activity; • protein serine/threonine phosphatase activity;
ترکیبات سلولی	• پوسته یاخته; • نوکلئوپلاسم; • microtubule organizing center; • اسکلت سلولی; • هسته یاخته; • protein phosphatase 4 complex; • سیتوپلاسم; • سیتوزول;
فرایند زیستی	• regulation of double-strand break repair via homologous recombination; • NIK/NF-kappaB signaling; • GO:0016576 protein dephosphorylation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5531
	56420
	ENSG00000149923
	ENSMUSG00000030697
	P60510
	P97470
	NM_001303503، NM_001303504، NM_001303506، NM_001303507، NM_002720 XM_006721061، NM_001303503، NM_001303504، NM_001303506، NM_001303507، NM_002720
	XM_006508049، NM_001360464 NM_019674، XM_006508049، NM_001360464
	NP_001290433، NP_001290435، NP_001290436، NP_002711، XP_006721124، XP_016878892، XP_016878893 NP_001290432، NP_001290433، NP_001290435، NP_001290436، NP_002711، XP_006721124، XP_016878892، XP_016878893
	XP_006508112، NP_001347393 NP_062648، XP_006508112، NP_001347393
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

زیرواحد کاتالیزوری سرین/ترئونین-پروتئین فسفاتاز ۴(به انگلیسی: Serine/threonine-protein phosphatase 4 catalytic subunit) آنزیمی است که در انسان توسط ژن PPP4C کدگذاری می‌شود.^[۴]^[۵]

فعل و انفعالات[ویرایش]

مشخص شده‌است که PPP4C با پروتئین‌های زیر تعامل پروتئین-پروتئین دارد:

CCDC6,^[۶]^[۷]
CCT2,^[۶]^[۸]
CCT3,^[۶]^[۸]
CCT4,^[۶]^[۸]
CCT5,^[۶]^[۸]
CCT6A,^[۶]^[۸]
CCT7,^[۶]^[۸]
IGBP1,^[۶]^[۸]^[۹]
PPP2R1A,^[۶]^[۷]
PPP4R1,^[۶]^[۷]^[۸]
REL,^[۱۰]
SMEK2,^[۶]^[۷]^[۸]
T-complex 1,^[۶]^[۸] و
TRAF6.^[۱۱]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030697 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.
↑ "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".
↑ ^۶٫۰۰ ^۶٫۰۱ ^۶٫۰۲ ^۶٫۰۳ ^۶٫۰۴ ^۶٫۰۵ ^۶٫۰۶ ^۶٫۰۷ ^۶٫۰۸ ^۶٫۰۹ ^۶٫۱۰ ^۶٫۱۱ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.
↑ ^۷٫۰ ^۷٫۱ ^۷٫۲ ^۷٫۳ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
↑ ^۸٫۰۰ ^۸٫۰۱ ^۸٫۰۲ ^۸٫۰۳ ^۸٫۰۴ ^۸٫۰۵ ^۸٫۰۶ ^۸٫۰۷ ^۸٫۰۸ ^۸٫۰۹ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.
↑ Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
↑ Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
↑ Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786. S2CID 27700566.

جهت مطالعه[ویرایش]

Brewis ND, Cohen PT (Dec 1992). "Protein phosphatase X has been highly conserved during mammalian evolution". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1171 (2): 231–3. doi:10.1016/0167-4781(92)90129-n. PMID 1336397.
Brewis ND, Street AJ, Prescott AR, Cohen PT (Mar 1993). "PPX, a novel protein serine/threonine phosphatase localized to centrosomes". The EMBO Journal. 12 (3): 987–96. doi:10.1002/j.1460-2075.1993.tb05739.x. PMC 413299. PMID 8384557.
Kloeker S, Bryant JC, Strack S, Colbran RJ, Wadzinski BE (Oct 1997). "Carboxymethylation of nuclear protein serine/threonine phosphatase X". The Biochemical Journal. 327 (Pt 2) (Pt 2): 481–6. doi:10.1042/bj3270481. PMC 1218819. PMID 9359419.
Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.
Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry. 274 (9): 5339–47. doi:10.1074/jbc.274.9.5339. PMID 10026142.
Hastie CJ, Carnegie GK, Morrice N, Cohen PT (May 2000). "A novel 50 kDa protein forms complexes with protein phosphatase 4 and is located at centrosomal microtubule organizing centres". The Biochemical Journal. 347 Pt 3 (Pt 3): 845–55. doi:10.1042/0264-6021:3470845. PMC 1221024. PMID 10769191.
Carnegie GK, Sleeman JE, Morrice N, Hastie CJ, Peggie MW, Philp A, Lamond AI, Cohen PT (May 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". Journal of Cell Science. 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. PMID 12668731.
Yeh PY, Yeh KH, Chuang SE, Song YC, Cheng AL (Jun 2004). "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation". The Journal of Biological Chemistry. 279 (25): 26143–8. doi:10.1074/jbc.M402362200. PMID 15073167.
Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (Nov 2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation". The Journal of Biological Chemistry. 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.
Zhou G, Boomer JS, Tan TH (Nov 2004). "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1". The Journal of Biological Chemistry. 279 (47): 49551–61. doi:10.1074/jbc.M410317200. PMID 15364934.
Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development. 19 (7): 827–39. doi:10.1101/gad.1286005. PMC 1074320. PMID 15805470.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000030697 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_9177794-4] Bastians H, Krebber H, Hoheisel J, Ohl S, Lichter P, Ponstingl H, Joos S (May 1997). "Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization". Genomics. 42 (1): 181–2. doi:10.1006/geno.1997.4693. PMID 9177794.

[entrez-5] "Entrez Gene: PPP4C protein phosphatase 4 (formerly X), catalytic subunit".

[pmid18715871-6] ۶٫۰۰ ^۶٫۰۱ ^۶٫۰۲ ^۶٫۰۳ ^۶٫۰۴ ^۶٫۰۵ ^۶٫۰۶ ^۶٫۰۷ ^۶٫۰۸ ^۶٫۰۹ ^۶٫۱۰ ^۶٫۱۱ Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi:10.1074/jbc.M803443200. PMC 2662017. PMID 18715871.

[pmid17353931-7] ۷٫۰ ^۷٫۱ ^۷٫۲ ^۷٫۳ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid16085932-8] ۸٫۰۰ ^۸٫۰۱ ^۸٫۰۲ ^۸٫۰۳ ^۸٫۰۴ ^۸٫۰۵ ^۸٫۰۶ ^۸٫۰۷ ^۸٫۰۸ ^۸٫۰۹ Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. PMID 16085932.

[pmid9647778-9] Chen J, Peterson RT, Schreiber SL (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochemical and Biophysical Research Communications. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.

[pmid9837938-10] Hu MC, Tang-Oxley Q, Qiu WR, Wang YP, Mihindukulasuriya KA, Afshar R, Tan TH (Dec 1998). "Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity". The Journal of Biological Chemistry. 273 (50): 33561–5. doi:10.1074/jbc.273.50.33561. PMID 9837938.

[pmid18634786-11] Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y (Aug 2008). "Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6". FEBS Letters. 582 (19): 2843–9. doi:10.1016/j.febslet.2008.07.014. PMID 18634786. S2CID 27700566.

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