CTBP1

CTBP1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1MX3, 4LCE, 4U6Q
معین‌کننده‌ها
نام‌های دیگر	CTBP1, C-terminal binding protein 1, BARS, HADDTS
شناسه‌های بیرونی	OMIM: 602618 MGI: 1201685 HomoloGene: 1015 GeneCards: CTBP1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۵ (موش)
پایان	33,432,338 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; • GO:0001106 transcription corepressor activity; • protein domain specific binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • NAD binding; • transcription factor binding; • protein C-terminus binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • oxidoreductase activity; • identical protein binding; • hydroxypyruvate reductase activity; • glyoxylate reductase (NADP+) activity; • protein homodimerization activity;
ترکیبات سلولی	• سیتوپلاسم; • transcription regulator complex; • transcription repressor complex; • نوکلئوپلاسم; • هسته یاخته; • سیتوزول; • presynaptic active zone cytoplasmic component; • glutamatergic synapse; • GABA-ergic synapse;
فرایند زیستی	• positive regulation of histone deacetylation; • دگرگونی یاخته‌; • GO:0009373 regulation of transcription, DNA-templated; • viral genome replication; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of cell cycle; • negative regulation of histone H4 acetylation; • protein phosphorylation; • white fat cell differentiation; • دگرگشت; • GO:0022415 viral process; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of histone acetylation; • negative regulation of cell population proliferation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1487
	13016
	ENSG00000159692
	ENSMUSG00000037373
	Q13363
	O88712
	NM_001328، XM_024453899، NM_001377186، NM_001377187، NM_001377188، NM_001377189، NM_001377190، NM_001377191، NM_001377192، NM_001377193، XM_047449633 NM_001012614، NM_001328، XM_024453899، NM_001377186، NM_001377187، NM_001377188، NM_001377189، NM_001377190، NM_001377191، NM_001377192، NM_001377193، XM_047449633
	NM_001198860، NM_001198861، NM_013502، NM_001310535، XM_030254105 NM_001198859، NM_001198860، NM_001198861، NM_013502، NM_001310535، XM_030254105
	NP_001319، XP_005272320، XP_016863253، XP_024309667، NP_001364115، NP_001364116، NP_001364117، NP_001364118، NP_001364119، NP_001364120، NP_001364121، NP_001364122 NP_001012632، NP_001319، XP_005272320، XP_016863253، XP_024309667، NP_001364115، NP_001364116، NP_001364117، NP_001364118، NP_001364119، NP_001364120، NP_001364121، NP_001364122
	NP_001185789، NP_001185790، NP_001297464، NP_038530، XP_030109965 NP_001185788، NP_001185789، NP_001185790، NP_001297464، NP_038530، XP_030109965
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین شمارهٔ ۱ متصل‌شونده به انتهای کربوکسیل (انگلیسی: C-terminal-binding protein 1) که با عنوانِ CtBP1 شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «CTBP1» کُدگذاری می‌شود.^[۴]

این پروتئین همچون CTBP2، یک مولکول بازدارندهٔ رونویسی دی‌ان‌ای (کورپرسور یا مانع‌یار) است و موجب خاموشی ژن‌ها می‌گردد.^[۵] این دو پروتئین، چندین نقش متفاوت در سلول ایفا می‌کنند و در تنظیم تغییرات اپیتلیالی و مزانشیمی و همچنین تنظیم متابولیسم یاخته (از طریق اتصال به NADH) نقش دارند.

در اثرِ پیرایش دگرسان (Alternative splicing)، چندین رونویسیِ متفاوت از این ژن وجود دارد که موجب می‌شوند گونه‌های متفاوتی از پروتئین از آن ساخته شود.^[۶]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000037373 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (April 1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem. 273 (15): 8549–52. doi:10.1074/jbc.273.15.8549. PMID 9535825.
↑ Turner J, Crossley M (September 1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMC 1170841. PMID 9724649.
↑ "Entrez Gene: CTBP1 C-terminal binding protein 1".

مشارکت‌کنندگان ویکی‌پدیا. «CTBP1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۹ مه ۲۰۱۸.

بیشتر بخوانید[ویرایش]

Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595.
Schaeper U; Boyd JM; Verma S; et al. (1995). "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (23): 10467–71. doi:10.1073/pnas.92.23.10467. PMC 40632. PMID 7479821. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Boyd JM; Subramanian T; Schaeper U; et al. (1993). "A region in the C-terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24-ras mediated transformation, tumorigenesis and metastasis". EMBO J. 12 (2): 469–78. PMC 413230. PMID 8440238. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Schaeper U; Subramanian T; Lim L; et al. (1998). "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif". J. Biol. Chem. 273 (15): 8549–52. doi:10.1074/jbc.273.15.8549. PMID 9535825. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Sundqvist A, Sollerbrant K, Svensson C (1998). "The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex". FEBS Lett. 429 (2): 183–8. doi:10.1016/S0014-5793(98)00588-2. PMID 9650586.
Fuks F, Milner J, Kouzarides T (1998). "BRCA2 associates with acetyltransferase activity when bound to P/CAF". Oncogene. 17 (19): 2531–4. doi:10.1038/sj.onc.1202475. PMID 9824164.
Sewalt RG; Gunster MJ; van der Vlag J; et al. (1999). "C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins". Mol. Cell. Biol. 19 (1): 777–87. PMC 83934. PMID 9858600. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Li S; Chen PL; Subramanian T; et al. (1999). "Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage". J. Biol. Chem. 274 (16): 11334–8. doi:10.1074/jbc.274.16.11334. PMID 10196224. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. doi:10.1073/pnas.96.12.6683. PMC 21975. PMID 10359772.
Criqui-Filipe P, Ducret C, Maira SM, Wasylyk B (1999). "Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation". EMBO J. 18 (12): 3392–403. doi:10.1093/emboj/18.12.3392. PMC 1171419. PMID 10369679.
Holmes M; Turner J; Fox A; et al. (1999). "hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation". J. Biol. Chem. 274 (33): 23491–8. doi:10.1074/jbc.274.33.23491. PMID 10438528. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Furusawa T, Moribe H, Kondoh H, Higashi Y (2000). "Identification of CtBP1 and CtBP2 as Corepressors of Zinc Finger-Homeodomain Factor δEF1". Mol. Cell. Biol. 19 (12): 8581–90. doi:10.1128/mcb.19.12.8581. PMC 84984. PMID 10567582.
Yu X, Baer R (2000). "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor". J. Biol. Chem. 275 (24): 18541–9. doi:10.1074/jbc.M909494199. PMID 10764811.
Koipally J, Georgopoulos K (2000). "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". J. Biol. Chem. 275 (26): 19594–602. doi:10.1074/jbc.M000254200. PMID 10766745.
Melhuish TA, Wotton D (2001). "The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF". J. Biol. Chem. 275 (50): 39762–6. doi:10.1074/jbc.C000416200. PMID 10995736.
Zhang CL, McKinsey TA, Lu JR, Olson EN (2001). "Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor". J. Biol. Chem. 276 (1): 35–9. doi:10.1074/jbc.M007364200. PMID 11022042.
Izutsu K; Kurokawa M; Imai Y; et al. (2001). "The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling". Blood. 97 (9): 2815–22. doi:10.1182/blood.V97.9.2815. PMID 11313276. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Palmer S; Brouillet JP; Kilbey A; et al. (2001). "Evi-1 transforming and repressor activities are mediated by CtBP co-repressor proteins". J. Biol. Chem. 276 (28): 25834–40. doi:10.1074/jbc.M102343200. PMID 11328817. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Schuierer M; Hilger-Eversheim K; Dobner T; et al. (2001). "Induction of AP-2alpha expression by adenoviral infection involves inactivation of the AP-2rep transcriptional corepressor CtBP1". J. Biol. Chem. 276 (30): 27944–9. doi:10.1074/jbc.M100070200. PMID 11373277. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)