SPTB

SPTB
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1S35, 3EDU, 3F57, 3KBT, 3KBU, 3LBX
معین‌کننده‌ها
نام‌های دیگر	SPTB, EL3, HS2, HSPTB1, SPH2, spectrin beta, erythrocytic
شناسه‌های بیرونی	OMIM: 182870 MGI: 98387 HomoloGene: 295 GeneCards: SPTB
موقعیت ژن (موش) کروموزوم کروموزوم ۱۲ (موش) نوار 12 C3|12 33.73 cM شروع 76,627,262 bp پایان 76,757,321 bp
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • actin filament binding • structural constituent of cytoskeleton • GO:0001948، GO:0016582 پیوند پروتئینی • ankyrin binding • actin binding ترکیبات سلولی • spectrin • intrinsic component of the cytoplasmic side of the plasma membrane • cell surface • cell cortex • actin cytoskeleton • spectrin-associated cytoskeleton • اسکلت سلولی • سیتوپلاسم • دستگاه گلژی • سیتوزول • GO:0009327 protein-containing complex فرایند زیستی • MAPK cascade • هدایت آسه • endoplasmic reticulum to Golgi vesicle-mediated transport • actin filament capping • cytoskeleton organization منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	6710	20741
آنسامبل	ENSG00000070182	ENSMUSG00000021061
یونی‌پروت	P11277	P15508
RefSeq (mRNA)	NM_000347، NM_001024858، XM_017021612، NM_001355436، NM_001355437، XM_024449699، XM_047431724، XM_047431725 XM_011537105، NM_000347، NM_001024858، XM_017021612، NM_001355436، NM_001355437، XM_024449699، XM_047431724، XM_047431725	NM_013675
RefSeq (پروتئین)	XP_011535407، XP_016877101، NP_001342365، NP_001342366، XP_024305467 NP_001020029، XP_011535407، XP_016877101، NP_001342365، NP_001342366، XP_024305467	ن/م
موقعیت (UCSC)	ن/م	Chr : 76.63 – 76.76 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

زنجیره بتا اسپکترین، اریتروسیت پروتئینی است که در انسان توسط ژن SPTB کدگذاری می شود.

جهت مطالعه

• Bennett V, Baines AJ (July 2001). "Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues". Physiological Reviews. 81 (3): 1353–92. doi:10.1152/physrev.2001.81.3.1353. PMID 11427698.
• Kanzaki A, Rabodonirina M, Yawata Y, Wilmotte R, Wada H, Ata K, Yamada O, Akatsuka J, Iyori H, Horiguchi M (October 1992). "A deletional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin Tokyo (beta 220/216)". Blood. 80 (8): 2115–21. doi:10.1182/blood.V80.8.2115.2115. PMID 1391962.
• Speicher DW, Weglarz L, DeSilva TM (July 1992). "Properties of human red cell spectrin heterodimer (side-to-side) assembly and identification of an essential nucleation site". The Journal of Biological Chemistry. 267 (21): 14775–82. doi:10.1016/S0021-9258(18)42107-2. PMID 1634521.
• Gallagher PG, Tse WT, Costa F, Scarpa A, Boivin P, Delaunay J, Forget BG (August 1991). "A splice site mutation of the beta-spectrin gene causing exon skipping in hereditary elliptocytosis associated with a truncated beta-spectrin chain". The Journal of Biological Chemistry. 266 (23): 15154–9. doi:10.1016/S0021-9258(18)98598-4. PMID 1840591.
• Tse WT, Lecomte MC, Costa FF, Garbarz M, Feo C, Boivin P, Dhermy D, Forget BG (September 1990). "Point mutation in the beta-spectrin gene associated with alpha I/74 hereditary elliptocytosis. Implications for the mechanism of spectrin dimer self-association". The Journal of Clinical Investigation. 86 (3): 909–16. doi:10.1172/JCI114792. PMC 296810. PMID 1975598.
• Yoon SH, Kentros CG, Prchal JT (July 1990). "Identification of an unusual deletion within homologous repeats of human reticulocyte beta-spectrin and probable peptide polymorphism". Gene. 91 (2): 297–302. doi:10.1016/0378-1119(90)90104-Y. PMID 1976574.
• Garbarz M, Tse WT, Gallagher PG, Picat C, Lecomte MC, Galibert F, Dhermy D, Forget BG (July 1991). "Spectrin Rouen (beta 220-218), a novel shortened beta-chain variant in a kindred with hereditary elliptocytosis. Characterization of the molecular defect as exon skipping due to a splice site mutation". The Journal of Clinical Investigation. 88 (1): 76–81. doi:10.1172/JCI115307. PMC 296005. PMID 2056132.
• Tse WT, Gallagher PG, Pothier B, Costa FF, Scarpa A, Delaunay J, Forget BG (July 1991). "An insertional frameshift mutation of the beta-spectrin gene associated with elliptocytosis in spectrin nice (beta 220/216)". Blood. 78 (2): 517–23. doi:10.1182/blood.V78.2.517.517. PMID 2070088.
• Winkelmann JC, Chang JG, Tse WT, Scarpa AL, Marchesi VT, Forget BG (July 1990). "Full-length sequence of the cDNA for human erythroid beta-spectrin". The Journal of Biological Chemistry. 265 (20): 11827–32. doi:10.1016/S0021-9258(19)38473-X. PMID 2195026.
• Winkelmann JC, Costa FF, Linzie BL, Forget BG (November 1990). "Beta spectrin in human skeletal muscle. Tissue-specific differential processing of 3' beta spectrin pre-mRNA generates a beta spectrin isoform with a unique carboxyl terminus". The Journal of Biological Chemistry. 265 (33): 20449–54. doi:10.1016/S0021-9258(17)30525-2. PMID 2243099.
• Coetzer T, Palek J, Lawler J, Liu SC, Jarolim P, Lahav M, Prchal JT, Wang W, Alter BP, Schewitz G (June 1990). "Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis". Blood. 75 (11): 2235–44. PMID 2346784.
• Winkelmann JC, Leto TL, Watkins PC, Eddy R, Shows TB, Linnenbach AJ, Sahr KE, Kathuria N, Marchesi VT, Forget BG (July 1988). "Molecular cloning of the cDNA for human erythrocyte beta-spectrin". Blood. 72 (1): 328–34. doi:10.1182/blood.V72.1.328.328. PMID 3390609.
• Prchal JT, Morley BJ, Yoon SH, Coetzer TL, Palek J, Conboy JG, Kan YW (November 1987). "Isolation and characterization of cDNA clones for human erythrocyte beta-spectrin". Proceedings of the National Academy of Sciences of the United States of America. 84 (21): 7468–72. Bibcode:1987PNAS...84.7468P. doi:10.1073/pnas.84.21.7468. PMC 299317. PMID 3478706.
• Pothier B, Morlé L, Alloisio N, Ducluzeau MT, Caldani C, Féo C, Garbarz M, Chaveroche I, Dhermy D, Lecomte MC (June 1987). "Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis". Blood. 69 (6): 1759–65. doi:10.1182/blood.V69.6.1759.1759. PMID 3580577.
• Wolfe LC, John KM, Falcone JC, Byrne AM, Lux SE (November 1982). "A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis". The New England Journal of Medicine. 307 (22): 1367–74. doi:10.1056/NEJM198211253072203. PMID 6215583.
• Speicher DW, Marchesi VT (1984). "Erythrocyte spectrin is comprised of many homologous triple helical segments". Nature. 311 (5982): 177–80. doi:10.1038/311177a0. PMID 6472478. S2CID 4340715.
• Carlier MF, Simon C, Cassoly R, Pradel LA (April 1984). "Interaction between microtubule-associated protein tau and spectrin". Biochimie. 66 (4): 305–11. doi:10.1016/0300-9084(84)90007-5. PMID 6743699.
• Goodman SR, Shiffer KA, Casoria LA, Eyster ME (September 1982). "Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis". Blood. 60 (3): 772–84. doi:10.1182/blood.V60.3.772.772. PMID 7104494.
• Schischmanoff PO, Winardi R, Discher DE, Parra MK, Bicknese SE, Witkowska HE, Conboy JG, Mohandas N (September 1995). "Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding". The Journal of Biological Chemistry. 270 (36): 21243–50. doi:10.1074/jbc.270.36.21243. PMID 7673158.