پرش به محتوا

CRTC1

از ویکی‌پدیا، دانشنامهٔ آزاد
CRTC1
معین‌کننده‌ها
نام‌های دیگرCRTC1, MECT1, TORC-1, TORC1, WAMTP1, CREB regulated transcription coactivator 1, MAML2, Mam-2
شناسه‌های بیرونیOMIM: 607536 MGI: 2142523 HomoloGene: 41607 GeneCards: CRTC1
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

23373

382056

آنسامبل

ENSG00000105662

ENSMUSG00000003575

یونی‌پروت

Q6UUV9

Q68ED7

RefSeq (mRNA)

NM_001098482، NM_015321، NM_025021، XM_005259833، XM_005259834، XM_005259835، XM_005259836، XM_006722710، XM_017026537، XM_017026538، XM_024451434، XM_047438529، XM_047438530، XM_047438531، XM_047438532 XM_011527842، NM_001098482، NM_015321، NM_025021، XM_005259833، XM_005259834، XM_005259835، XM_005259836، XM_006722710، XM_017026537، XM_017026538، XM_024451434، XM_047438529، XM_047438530، XM_047438531، XM_047438532

XM_006509699، XM_006509700، XM_006509704، XM_011242309، XM_011242310، XM_011242311، XM_011242312، XM_011242313، XM_011242314، XM_030243653، XM_036154147، XM_036154148، XM_036154149 NM_001004062، XM_006509699، XM_006509700، XM_006509704، XM_011242309، XM_011242310، XM_011242311، XM_011242312، XM_011242313، XM_011242314، XM_030243653، XM_036154147، XM_036154148، XM_036154149

RefSeq (پروتئین)

NP_056136، XP_005259890، XP_005259891، XP_005259892، XP_005259893، XP_006722773، XP_011526144، XP_016882025، XP_016882026، XP_016882027، XP_024307202 NP_001091952، NP_056136، XP_005259890، XP_005259891، XP_005259892، XP_005259893، XP_006722773، XP_011526144، XP_016882025، XP_016882026، XP_016882027، XP_024307202

XP_006509762، XP_006509763، XP_006509767، XP_011240611، XP_011240612، XP_011240613، XP_011240614، XP_011240615، XP_011240616، XP_030099513، XP_036010040، XP_036010041، XP_036010042، NP_001391344، NP_001391345، NP_001391346، NP_001391347، NP_001391348، NP_001391349، NP_001391350، NP_001391351، NP_001391352، NP_001391353، NP_001391354، NP_001391355، NP_001391356، NP_001391357، NP_001391358، NP_001391359 NP_001004062، XP_006509762، XP_006509763، XP_006509767، XP_011240611، XP_011240612، XP_011240613، XP_011240614، XP_011240615، XP_011240616، XP_030099513، XP_036010040، XP_036010041، XP_036010042، NP_001391344، NP_001391345، NP_001391346، NP_001391347، NP_001391348، NP_001391349، NP_001391350، NP_001391351، NP_001391352، NP_001391353، NP_001391354، NP_001391355، NP_001391356، NP_001391357، NP_001391358، NP_001391359

موقعیت (UCSC)ن/مChr : 70.84 – 70.89 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

هم‌فعال‌ساز ۱ رونویسی تنظیم‌شونده توسط پروتئین متصل‌شونده به عناصر پاسخ‌دهنده به آدنوزین مونوفسفات حلقه‌ای (انگلیسی: CREB-regulated transcription coactivator 1) که به‌اختصار CRTC1 گقته می‌شود و پیش‌تر به نامِ TORC1 هم شناخته می‌شد، یک پروتئین است که در انسان توسط ژن «CRTC1» کُدگذاری می‌شود.[۴][۵][۶][۷]

این پروتئین در مغز و کبد جنین و همچنین عضلات اسکلتی، قلب و غدد بزاقی بزرگسالان[۸] و بخش‌های متفاوتی از دستگاه عصبی مرکزی[۹] آنان بیان و ساخته می‌شود.

اهمیت بالینی[ویرایش]

منابع[ویرایش]

  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000003575 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ (Feb 2003). "t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway". Nature Genetics. 33 (2): 208–13. doi:10.1038/ng1083. PMID 12539049.
  5. ↑ Conkright MD, Canettieri G, Screaton R, Guzman E, Miraglia L, Hogenesch JB, Montminy M (Aug 2003). "TORCs: transducers of regulated CREB activity". Molecular Cell. 12 (2): 413–23. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
  6. ↑ Iourgenko V, Zhang W, Mickanin C, Daly I, Jiang C, Hexham JM, Orth AP, Miraglia L, Meltzer J, Garza D, Chirn GW, McWhinnie E, Cohen D, Skelton J, Terry R, Yu Y, Bodian D, Buxton FP, Zhu J, Song C, Labow MA (Oct 2003). "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 100 (21): 12147–52. doi:10.1073/pnas.1932773100. PMC 218727. PMID 14506290.
  7. ↑ "Entrez Gene: CRTC1 CREB regulated transcription coactivator 1".
  8. ↑ Huret J-L. "CRTC1 (CREB regulated transcription coactivator 1)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. INSERM U 935, Genetics, Dept Medical Information, University Hospital of Poitiers.
  9. ↑ Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  10. ↑ Parra-Damas A, Valero J, Chen M, España J, Martín E, Ferrer I, Rodríguez-Alvarez J, Saura CA (Apr 2014). "Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages". The Journal of Neuroscience. 34 (17): 5776–87. doi:10.1523/JNEUROSCI.5288-13.2014. PMID 24760838.
  11. ↑ Mannick JB, Morris M, Hockey HU, Roma G, Beibel M, Kulmatycki K, et al. (11 July 2018). "TORC1 inhibition enhances immune function and reduces infections in the elderly". Science Translational Medicine. 10 (449): eaaq1564. doi:10.1126/scitranslmed.aaq1564. {{cite journal}}: Unknown parameter |laysource= ignored (help); Unknown parameter |laysummary= ignored (help)

پیوند به بیرون[ویرایش]

برای مطالعهٔ بیشتر[ویرایش]

  • Kovács KA, Steullet P, Steinmann M, Do KQ, Magistretti PJ, Halfon O, Cardinaux JR (Mar 2007). "TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity". Proceedings of the National Academy of Sciences of the United States of America. 104 (11): 4700–5. doi:10.1073/pnas.0607524104. PMC 1838663. PMID 17360587.
  • Takemori H, Kajimura J, Okamoto M (Jul 2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". The FEBS Journal. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599.
  • Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  • Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G (Jan 2004). "Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors". Experimental Cell Research. 292 (1): 21–8. doi:10.1016/j.yexcr.2003.09.007. PMID 14720503.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, Guzman E, Niessen S, Yates JR, Takemori H, Okamoto M, Montminy M (Oct 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
  • Bittinger MA, McWhinnie E, Meltzer J, Iourgenko V, Latario B, Liu X, Chen CH, Song C, Garza D, Labow M (Dec 2004). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins". Current Biology. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160.
  • Behboudi A, Winnes M, Gorunova L, van den Oord JJ, Mertens F, Enlund F, Stenman G (Jun 2005). "Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion". Genes, Chromosomes & Cancer. 43 (2): 202–5. doi:10.1002/gcc.20168. PMID 15729701.
  • Komiya T, Park Y, Modi S, Coxon AB, Oh H, Kaye FJ (Oct 2006). "Sustained expression of Mect1-Maml2 is essential for tumor cell growth in salivary gland cancers carrying the t(11;19) translocation". Oncogene. 25 (45): 6128–32. doi:10.1038/sj.onc.1209627. PMID 16652146.
  • Siu YT, Chin KT, Siu KL, Yee Wai Choy E, Jeang KT, Jin DY (Jul 2006). "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology. 80 (14): 7052–9. doi:10.1128/JVI.00103-06. PMC 1489057. PMID 16809310.
  • Katoh Y, Takemori H, Lin XZ, Tamura M, Muraoka M, Satoh T, Tsuchiya Y, Min L, Doi J, Miyauchi A, Witters LA, Nakamura H, Okamoto M (Jun 2006). "Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade". The FEBS Journal. 273 (12): 2730–48. doi:10.1111/j.1742-4658.2006.05291.x. PMID 16817901.
  • Okabe M, Miyabe S, Nagatsuka H, Terada A, Hanai N, Yokoi M, Shimozato K, Eimoto T, Nakamura S, Nagai N, Hasegawa Y, Inagaki H (Jul 2006). "MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma". Clinical Cancer Research. 12 (13): 3902–7. doi:10.1158/1078-0432.CCR-05-2376. PMID 16818685.
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