از ویکی‌پدیا، دانشنامهٔ آزاد
مولکول ۱۲ مرتبط با خودخواری (انگلیسی : Autophagy related 12 پروتئین است که در انسان توسط ژن «ATG12 » کُدگذاری می‌شود.[۴] [۵]
برای شروع خودخواری لازم است این مولکول به پروتئین ATG5 از طریق یک سامانهٔ اتصالی شبه یوبیکوتینی ، پیوند کووالانسی ایجاد کند. سپس این ترکیب مولکولی دوگانه خودش باعث اتصال پروتئین ATG8 به فسفاتیدیل اتانل آمین می‌گردد.[۶]
این مولکول همچنین در آپوپتوز هم دخالت دارد و اینکار را از طریق تعامل با مولکول‌های ضد آپوپتوزی خانواده Bcl-2 انجام می‌دهد.[۷]
↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032905 - Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Mizushima N, Sugita H, Yoshimori T, Ohsumi Y (Jan 1999). "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy" . J Biol Chem . 273 (51): 33889–33892. doi :10.1074/jbc.273.51.33889 PMID 9852036 . ↑ "Entrez Gene: ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae)" .↑ J. Geng, and D. J. Klionsky, 'The Atg8 and Atg12 Ubiquitin-Like Conjugation Systems in Macroautophagy. 'Protein Modifications: Beyond the Usual Suspects' Review Series', EMBO Rep, 9 (2008), 859-64.
↑ A. D. Rubinstein, M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi, 'The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis', Mol Cell, 44 (2011), 698-709
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