گیرنده فریب‌گر ۲

TNFRSF10D
معین‌کننده‌ها
نام‌های دیگر	TNFRSF10D, CD264, DCR2, TRAIL-R4, TRAILR4, TRUNDD, tumor necrosis factor receptor superfamily member 10d, TNF receptor superfamily member 10d
شناسه‌های بیرونی	OMIM: 603614 HomoloGene: 136778 GeneCards: TNFRSF10D
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transmembrane signaling receptor activity; • tumor necrosis factor-activated receptor activity; • TRAIL binding;
ترکیبات سلولی	• integral component of membrane; • integral component of plasma membrane; • membrane; • پوسته یاخته; • cell surface;
فرایند زیستی	• multicellular organism development; • response to lipopolysaccharide; • inflammatory response; • negative regulation of apoptotic process; • regulation of cell population proliferation; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 پاسخ ایمنی; • GO:0072468 ورارسانی پیام; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • tumor necrosis factor-mediated signaling pathway; • regulation of apoptotic process; • leukocyte migration; • apoptotic signaling pathway; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • cell surface receptor signaling pathway;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	8793
	ن/م
	ENSG00000173530
	ن/م
	Q9UBN6
	ن/م
	NM_003840
	ن/م
	NP_003831
	ن/م
	ویکی‌داده
مشاهده/ویرایش انسان

گیرنده فریب‌گر ۲ (انگلیسی: Decoy receptor 2) که با نام‌های TRAILR4، DCR2 و TNFRSF10D نیز شناخته می‌شود، یک گیرندهٔ سطح سلول از ابرخانواده گیرنده‌های فاکتور نکروز تومور است.^[۲]^[۳]^[۴]

این گیرنده نقش محافظتی در برابر خزان یاخته‌ای وابسته به پروتئین تریل ایفا می‌کند.^[۴]

منابع[ویرایش]

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.
↑ Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling" (PDF). FEBS Lett. 424 (1–2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512.
↑ ^۴٫۰ ^۴٫۱ "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

مشارکت‌کنندگان ویکی‌پدیا. «Decoy receptor 2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۱۹.

برای مطالعهٔ بیشتر[ویرایش]

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Sun SY, Yue P, Chen X, et al. (2002). "The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells". Cancer Res. 62 (8): 2430–6. PMID 11956107.
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Hasel C, Dürr S, Rau B, et al. (2003). "In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas". Lab. Invest. 83 (6): 825–36. doi:10.1097/01.lab.0000073126.56932.46. PMID 12808117.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9382840-2] Marsters SA, Sheridan JP, Pitti RM, Huang A, Skubatch M, Baldwin D, Yuan J, Gurney A, Goddard AD, Godowski P, Ashkenazi A (Feb 1998). "A novel receptor for Apo2L/TRAIL contains a truncated death domain". Curr Biol. 7 (12): 1003–6. doi:10.1016/S0960-9822(06)00422-2. PMID 9382840.

[pmid9537512-3] Pan G, Ni J, Yu G, Wei YF, Dixit VM (Apr 1998). "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling" (PDF). FEBS Lett. 424 (1–2): 41–5. doi:10.1016/S0014-5793(98)00135-5. PMID 9537512.

[entrez-4] ۴٫۰ ^۴٫۱ "Entrez Gene: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain".

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